Aligos Therapeutics, Inc. is a biotechnology company located in South San Francisco, California that is developing novel medicines to treat liver diseases in virology, inflammation/fibrosis and oncology. Aligos is pursuing the development of both oligonucleotide-based and small molecule therapeutics, each addressing major commercial market opportunities.
At Aligos, our science is the key to our success, and to improving patients’ quality of life. Our pipeline of developing novel compounds and investigative therapies reflects our commitment to bring innovative products to patients with unmet needs in the area of liver diseases. This is an exciting opportunity to become an early employee of a high energy, pre-IPO Research and Development company. We are looking for an enthusiastic scientist who understands and appreciates the entrepreneurial environment of a “start-up” and who is willing to do what it takes to contribute to the success of the company.
This position will report to the Director of Toxicology. In this role, the candidate will be responsible for the following key aspects:
- Design and oversee nonclinical toxicology programs for Aligos small molecule and oligonucleotide discovery and development programs, including both in vitro and in vivo studies.
- Act as a functional representative on discovery project teams. Help develop and implement de-risking and screening strategies to support lead optimization.
- Work with external CRO and internally with Operations Manager for study placement and protocol development, serve as a study monitor, review and finalize study reports.
- Analyze, interpret, and summarize nonclinical safety data. Communicate and present findings and recommendations to internal project teams.
- Contribute to writing of regulatory documents that are required for worldwide filings
- Lead investigative efforts into mechanisms of toxicity as needed.
- Ensure timely and accurate nonclinical study deliverables of projects to enable compound progression and decision-making.
- Opportunity to be a functional representative on development teams as the discovery projects transition into development
Qualifications and requirements:
- PhD or equivalent in toxicology, pharmacology, or related discipline. Post-doctoral training and DABT certification is desirable.
- Experience in the pharmaceutical industry (minimum of 1 to 3 years)
- Must have experience in outsourcing and managing studies to contract research organizations.
- Must have working knowledge of regulatory documents and/or proven track record as contributing scientist for IND/NDA, report review and writing. Knowledge of GLP, GCP, drug development and regulatory guidelines.
- Strong scientific background in toxicology and scientific aptitude with excellent critical thinking, strong decision-making based on scientific principles, complex problem solving, critical data analysis and interpretation skills.
- The ability to work independently and have the ability to work effectively and collaboratively on cross-functional project teams. Excellent interpersonal and organizational skills, excellent oral/written communication, proven track record of teamwork, ability to multitask and prioritize to delivery results within tight timelines is a must.
Interested parties should provide a detailed resume including references to email@example.com